After Owen Wilson overstayed his welcome in “Wedding Crashers,” he morphed into obnoxious houseguest Randolph Dupree, who also suffers from arrested development.

Thirtysomething Dupree (Wilson) is an amiable, good-hearted but wayward, disaster-prone slacker who – jobless and homeless - ‘temporarily’ moves in with his newlywed best buddy Carl (Matt Dillon) and schoolteacher wife Molly (Kate Hudson), promising, “Wheels of change are in motion.”

While he means well, guileless Dupree has never truly been ‘domesticated’ and the results are catastrophic as he wreaks havoc on their house and their lives. Meanwhile, ever-serious Carl – under increasing pressure from his tyrannical new father-in-law (Michael Douglas), a wily Southern California land developer - is becoming a workaholic, as understanding Molly and the neighbors are increasingly disarmed by Dupree’s carefree charm and unintentional wisdom.

Quirky Owen Wilson embodies Dupree’s odd, idiosyncratic eccentricity, while Emmy award-winning directors Anthony & Joe Russo (TV’s “Arrested Development”) mine both the comedic and the dramatic in first-time screenwriter Michael Le Sieur’s script which delves into how an adolescent ‘best-friend’ relationship is inevitably changed by marriage and maturity. While the zany, contrived situations are absurd, particularly Dupree’s derivative “Last Tango in Paris” seduction, the characters, nevertheless, maintain an emotional, if calculated, reality.

Seven-time Tour de France champion Lane Armstrong not only makes a cameo appearance but becomes Dupree’s unconventional and obsessional hero: “That guy has done more with one testicle than you have with both arms!” And Seth Rogan (“40 Year Old Virgin”) scores as Carl’s unhappily-married friend Neil.

It isn’t in the league of George S. Kaufman’s “The Man Who Came to Dinner,” but on the Granger Movie Gauge of 1 to 10, “You, Me and Dupree” is a fast-paced, amusing 7, advising, “Stay loose, stay liquid and laugh a lot.”